GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs10461617 | 1 | rs832578 | chr5:56164223 | C5orf35 | chr5:56205103-56213010:+ | 0.59 | 6.49 | 1.13E-9 | Type 2 diabetes |
| UCEC | cis | rs10461617 | 1 | rs832582 | chr5:56177743 | C5orf35 | chr5:56205103-56213010:+ | 0.6 | 6.24 | 4.09E-9 | Type 2 diabetes |
| UCEC | cis | rs10461617 | 1 | rs832583 | chr5:56178217 | C5orf35 | chr5:56205103-56213010:+ | 0.6 | 6.24 | 4.09E-9 | Type 2 diabetes |
| UCEC | cis | rs10461617 | 1 | rs832584 | chr5:56179212 | C5orf35 | chr5:56205103-56213010:+ | -0.58 | -6.2 | 5.2E-9 | Type 2 diabetes |
| UCEC | cis | rs199347 | 1 | rs858239 | chr7:23286315 | GPNMB | chr7:23286316-23314728:+ | -0.4 | -4.8 | 3.73E-6 | Parkinson's disease |
| UCEC | cis | rs199347 | 1 | rs858240 | chr7:23284237 | GPNMB | chr7:23286316-23314728:+ | -0.4 | -4.63 | 7.65E-6 | Parkinson's disease |
| UCEC | cis | rs10461617 | 1 | rs860580 | chr5:56149429 | C5orf35 | chr5:56205103-56213010:+ | -0.63 | -7.05 | 5.74E-11 | Type 2 diabetes |
| UCEC | cis | rs10461617 | 1 | rs861283 | chr5:56184610 | C5orf35 | chr5:56205103-56213010:+ | 0.6 | 6.24 | 4.09E-9 | Type 2 diabetes |
| UCEC | cis | rs10461617 | 1 | rs863840 | chr5:56128999 | C5orf35 | chr5:56205103-56213010:+ | 0.66 | 6.72 | 3.5E-10 | Type 2 diabetes |
| UCEC | cis | rs10461617 | 1 | rs866222 | chr5:56184444 | C5orf35 | chr5:56205103-56213010:+ | 0.6 | 6.24 | 4.09E-9 | Type 2 diabetes |
| UCEC | cis | rs2130392 | 1 | rs873686 | chr4:185638876 | MLF1IP | chr4:185615220-185655286:- | 0.41 | 5.75 | 4.8E-8 | Kawasaki disease |
| UCEC | cis | rs4660306 | 1 | rs882803 | chr1:45976147 | CCDC163P | chr1:45960581-45965646:- | -0.48 | -6.43 | 1.55E-9 | Homocysteine levels |
| UCEC | cis | rs1577917 | 1 | rs884841 | chr6:86680300 | SNHG5 | chr6:86386726-86388451:- | -0.48 | -5.75 | 4.65E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs889312 | 1 | rs889312 | chr5:56031884 | C5orf35 | chr5:56205103-56213010:+ | 0.39 | 4.51 | 1.31E-5 | Breast cancer (early onset);Breast cancer |
| UCEC | cis | rs10461617 | 1 | rs9283717 | chr5:56078659 | C5orf35 | chr5:56205103-56213010:+ | 0.58 | 6.18 | 5.74E-9 | Type 2 diabetes |